General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter NMU1R Total Internalization U2OS Cell Line, 2 vials. (93-0782C3)
The PathHunter NMU1R Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of nMU1R via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged nMU1R and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the nMU1R receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Chlamydia trachomatis; Serovar D; Strain: UW-3/Cx
Chlamydia trachomatis serovar D strain UW-3/Cx is propagated in McCoy [McCoy B] cells (ATCC CRL-1696). This strain was isolated from the cervix of an asymptomatic human patient. This product has applications in infectious disease and sexually transmitted disease research.
Eurofins Discoverx PathHunter CHO-K1 mPPYR1 (mNPY4R) β-Arrestin Cell Line, 2 vials. (93-0774C2)
The PathHunter mPPYR1 (mNPY4R) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. pancreatic polypeptide) based activation of mPPYR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mPPYR1 and EA-tagged β-Arrestin-2. Activation of mPPYR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 CXCR4 Gi Cell Line, 2 vials. (95-0081C2)
The cAMP Hunter CXCR4 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL12/SDF-1α) based activation of CXCR4 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CXCR4, a naturally Gi/Go coupled GPCR. Upon activation of CXCR4, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Medchemexpress LLC CD47 Human HEK293 10ug
CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1 affecting signal transduction cardiovascular homeostasis inflammation apoptosis angiogenesis self-renewal and Immunomodulatory It regulates pulmonary endothelin EDN1 signaling acts as a pressor in blood pressure regulation and is critical for memory formation CD47 Protein Human (HEK293) is the recombinant human-derived CD47 protein expressed by HEK293 with tag free
Biochain Institute Inc Matched Pair - Paraffin Tissue Sections - Human Primary and Matched Metastatic Tumor (PM): Stomach, 5 x2 slides /PK
BioChain's human paraffin tissue (FFPE) section matched pair products include: Primary Pair (PP), Primary and Metastatic Pair (PM). PP consists of paraffin tissue sections of primary tumor and its adjacent normal tissue; PM consists of paraffin tissue sections of primary tumor and corresponding metastatic tumor. Paraffin tissue sections in each pair are prepared from the same donor. This product line is ideal for localization of tumor- specific genes and tumor metastatic genes.
Biochain Institute Inc Paraffin Tissue Section - Human Skin Tumor: Squamous Cell Carcinoma, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Biochain Institute Inc Paraffin Tissue Section - Human Kidney Tumor, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
ATCC Malassezia globosa; CBS 7966
An ampoule containing viable cells (may include spores and mycelium) suspended in cryoprotectant.
Genscript Corporation CHO-K1/CD40 Stable Cell Line
Cluster of differentiation 40 CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects
Eurofins Discoverx PathHunter DRD1 Total GPCR Internalization U2OS Cell Line, 2 vials. (93-0748C3)
The PathHunter DRD1 Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of DRD1 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged DRD1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the DRD1 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Section - Dementia: Brain: Hippocampus, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx PathHunter U2OS EpoR/EpoR Dimerization Cell Line, 2 vials. (93-0965C3)
The PathHunter EpoR/EpoR Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. erythropoietin) induced dimerization of EpoR/EpoR receptors. This product uses EFC technology. The cell line included overexpresses EpoR target protein fused to PK alongside EpoR target protein fused to EA. Upon ligand-induced dimerization of EpoR/EpoR, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
